Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis.

  title={Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis.},
  author={Liying Wang and James M· Antonini and Yon Rojanasakul and Vincent Castranova and James F. Scabilloni and Robert R. Mercer},
  journal={Journal of cellular physiology},
  volume={194 2},
Induction of apoptosis has been associated with a variety of exposures which result in inflammatory and fibrotic lung disorders. Macrophages are key regulatory cells in the lung; however, the role of apoptotic macrophages in those pulmonary disorders is not well characterized. In the present investigation, apoptotic macrophages were instilled into the lungs of rats to study directly the pulmonary responses to apoptotic cells. The effects of apoptotic macrophages on lung inflammation and… CONTINUE READING


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