Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain

  title={Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain},
  author={C. Patte-Mensah and L. Meyer and O. Taleb and A. Mensah-Nyagan},
  journal={Progress in Neurobiology},
  • C. Patte-Mensah, L. Meyer, +1 author A. Mensah-Nyagan
  • Published 2014
  • Medicine
  • Progress in Neurobiology
  • Because the treatment and management of neuropathic pain are extremely complicated, the characterization of novel analgesics and neuroprotectors with safe toxicological profiles is a crucial need to develop efficient therapies. Several investigations revealed that the natural neurosteroid allopregnanolone (AP) exerts analgesic, neuroprotective, antidepressant and anxiolytic effects. These effects result from AP ability to modulate GABA(A), glycine, L- and T-type calcium channels. It has been… CONTINUE READING
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