Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain

@article{PatteMensah2014PotentialRO,
  title={Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain},
  author={Christine Patte‐Mensah and Laurence Meyer and Omar Taleb and Ayiko{\'e} Guy Mensah-Nyagan},
  journal={Progress in Neurobiology},
  year={2014},
  volume={113},
  pages={70-78}
}

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References

SHOWING 1-10 OF 131 REFERENCES

Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats

TLDR
Investigation of the role of AP and its therapeutic potential in rats that showed hyperalgesic behavior after undergoing spinal nerve ligation suggests changes in spinal AP biosynthesis are involved in the pathogenesis of neuropathic pain following peripheral nerve injury.

Evaluation of the analgesic effect of neurosteroids and their possible mechanism of action.

TLDR
P and 4-CD pretreatment potentiated the analgesic effect of morphine and nimodipine in both the models of pain sensitivity and neurosteroids produce an antinociceptive effect which may be mediated by modulation of GABAergic and/or opiodergic mechanisms as well as voltage gated calcium channels.

Docetaxel‐induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model

TLDR
It is demonstrated that treatment with dihydroprogesterone (DHP) or progesterone (P) counteracts docetaxel‐induced neuropathy, preventing nerve conduction and thermal threshold changes, and degeneration of skin nerves in the foodpad.

Effect of Methylprednisolone on Neuropathic Pain and Spinal Glial Activation in Rats

TLDR
Systemic and intrathecal methylprednisolone inhibited spinal glial activation and the development and maintenance of a neuropathic pain state in a rat model of spinal nerve ligation.

Evidence for a key role of steroids in the modulation of pain

Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation

...