Potential role of TGF-beta in diabetic nephropathy.

  title={Potential role of TGF-beta in diabetic nephropathy.},
  author={Barbara Hoffman and Kumar Sharma and Fuad N. Ziyadeh},
  journal={Mineral and electrolyte metabolism},
  volume={24 2-3},
Renal injury in diabetes mellitus is a major cause of morbidity and mortality. Several manifestations of diabetic nephropathy may be a consequence of altered production and/or response to cytokines or growth factors. Transforming growth factor-beta (TGF-beta) is one such factor because it promotes renal cell hypertrophy and regulates the production of extracellular matrix molecules. In addition, high ambient glucose increases TGF-beta1 mRNA and protein level in cultured proximal tubular cells… CONTINUE READING