Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates.

@article{Yanamadala2003PotentialRO,
  title={Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates.},
  author={Sunitha Yanamadala and Mats Ljungman},
  journal={Molecular cancer research : MCR},
  year={2003},
  volume={1 10},
  pages={747-54}
}
Defects in DNA mismatch repair (MMR) are common in human cancers, confer tolerance to certain types of chemotherapeutic agents, and lead to genomic instability. In addition to their mismatch-correcting roles during DNA replication, MMR proteins can bind to certain DNA lesions and signal p53 and apoptosis by an unknown mechanism. To further study the mechanism by which the MMR protein MLH1 is involved in the induction of p53 and apoptosis, we exposed the colon carcinoma cell line HCT116 (MLH1… CONTINUE READING

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Photoproducts in transcriptionally active DNA induce signal transduction to delay UVMolecular

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