Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase.

@article{Stamatovic2003PotentialRO,
  title={Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase.},
  author={Svetlana M. Stamatovic and Richard F. Keep and Steven L. Kunkel and Anuska V. Andjelkovic},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 22},
  pages={
          4615-28
        }
}
The expression of the monocyte chemoattractant protein-1 (MCP-1) receptor CCR2 by brain endothelial cells suggests that MCP-1 may have other functions than purely driving leukocyte migration into brain parenchyma during inflammation. This study examines one of these potential novel roles of MCP-1 regulation of endothelial permeability using primary cultures of mouse brain endothelial cells. MCP-1 induces reorganization of actin cytoskeleton (stress fiber formation) and redistribution of tight… CONTINUE READING
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