Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy.

@article{Ciravolo2012PotentialRO,
  title={Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy.},
  author={Valentina Ciravolo and Veronica Huber and Gaia Cristina Ghedini and Elisabetta Venturelli and Francesca Bianchi and Manuela Campiglio and Daniele Morelli and Antonello Villa and Pamela Della Mina and Sylvie M{\'e}nard and Paola Filipazzi and Licia Rivoltini and Elda Tagliabue and Serenella M Pupa},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 2},
  pages={658-67}
}
Exosomes are endosome-derived nanovesicles actively released into the extracellular environment and biological fluids, both under physiological and pathological conditions, by different cell types. We characterized exosomes constitutively secreted by HER2-overexpressing breast carcinoma cell lines and analyzed in vitro and in vivo their potential role in interfering with the therapeutic activity of the humanized antibody Trastuzumab and the dual tyrosine kinase inhibitor (TKI) Lapatinib anti… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 38 references

HER-2 as a target for breast cancer therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009
View 4 Excerpts
Highly Influenced

Breast cancer - specificmutations in CK 1 epsilon inhibit Wnt / beta - catenin and activate the Wnt / Rac 1 / JNK and NFAT pathways to decrease cell adhesion and promote cell migration

R Gennari, S Ménard, +11 authors A Zambelli
BreastCancerRes • 2010

Role of soluble HER 2 extracellular domain in HER 2 - mediated tumor growth and in response to Trastuzumab

V Guarneri, E Barbieri, MV Dieci, F Piacentini, P Conte
J Cell Physiol • 2010
View 1 Excerpt

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