Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy.

  title={Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy.},
  author={Valentina Ciravolo and Veronica Huber and Gaia Cristina Ghedini and Elisabetta Venturelli and Francesca Bianchi and Manuela Campiglio and Daniele Morelli and Antonello Villa and Pamela Della Mina and Sylvie M{\'e}nard and Paola Filipazzi and Licia Rivoltini and Elda Tagliabue and Serenella M Pupa},
  journal={Journal of cellular physiology},
  volume={227 2},
Exosomes are endosome-derived nanovesicles actively released into the extracellular environment and biological fluids, both under physiological and pathological conditions, by different cell types. We characterized exosomes constitutively secreted by HER2-overexpressing breast carcinoma cell lines and analyzed in vitro and in vivo their potential role in interfering with the therapeutic activity of the humanized antibody Trastuzumab and the dual tyrosine kinase inhibitor (TKI) Lapatinib anti… CONTINUE READING


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