Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne

@inproceedings{Melnik2013PotentialRO,
  title={Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne},
  author={Bodo C Melnik and C C Zouboulis},
  booktitle={Experimental dermatology},
  year={2013}
}
Acne in adolescents of developed countries is an epidemic skin disease and has currently been linked to the Western diet (WD). It is the intention of this viewpoint to discuss the possible impact of WD-mediated nutrient signalling in the pathogenesis of acne. High glycaemic load and dairy protein consumption both increase insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) that is superimposed on elevated IGF-1 signalling of puberty. The cell's nutritional status is primarily sensed… CONTINUE READING
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Interaction of acne risk-enhancing gene polymorphisms on FoxO1-/mTORC1 mediated nutrient signalling of Western diet

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