Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome

Abstract

The potential role of AKT/mTOR signalling proteins and its association with the Raf-MEK-ERK pathway was investigated in hairy cell leukaemia (HCL). BRAFV600E expression and activated forms of AKT, mTOR, ERK1/2, p70S6k and 4E-BP1 were immunohistochemically assessed in 77 BM biopsies of HCL patients and correlated with clinicopathological and BM microvascular… (More)
DOI: 10.1038/srep21252

Topics

8 Figures and Tables

Cite this paper

@inproceedings{Lakiotaki2016PotentialRO, title={Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome}, author={Eleftheria Lakiotaki and Georgia Levidou and Maria K Angelopoulou and Christos G. Adamopoulos and Gerassimos A. Pangalis and George Z. Rassidakis and Theodoros Vassilakopoulos and Gabriella Gainaru and Pagona Flevari and Sotirios Sachanas and Angelica A. Saetta and Athanasia Sepsa and Maria Moschogiannis and Christina Kalpadakis and Nikolaos Tsesmetzis and Vassilios Milionis and Ilenia Chatziandreou and Irene Thymara and Panayiotis G. Panayiotidis and Maria Dimopoulou and Eleni Plata and Konstantinos Konstantopoulos and Efstratios S. Patsouris and Christina Piperi and Penelope Korkolopoulou}, booktitle={Scientific reports}, year={2016} }