Potential role of ABCA7 in cellular lipid efflux to apoA-I.

  title={Potential role of ABCA7 in cellular lipid efflux to apoA-I.},
  author={Patrick Linsel-Nitschke and Andreas Werner Jehle and Jing Shan and Guoqing Cao and Desa Bacic and Debin Lan and Nan Wang and Alan Richard Tall},
  journal={Journal of lipid research},
  volume={46 1},
ABCA7 is homologous to ABCA1 and has recently been shown in cell culture to bind apolipoprotein A-I (apoA-I) and to promote the efflux of phospholipids. However, it is not known if ABCA7 promotes lipid efflux in vivo. When expressed in HEK293 cells, both human and mouse ABCA7 promoted phospholipid efflux to apoA-I but no detectable cholesterol efflux. However, genetic knockdown of ABCA7 in mouse peritoneal macrophages did not affect phospholipid or cholesterol efflux to apoA-I. Moreover, in… CONTINUE READING
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