Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28.

@article{Hurtado1995PotentialRO,
  title={Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28.},
  author={Jose C. Hurtado and Soo Hyun Kim and Karen E. Pollok and Zang Hee Lee and Byoung S. Kwon},
  journal={Journal of immunology},
  year={1995},
  volume={155 7},
  pages={3360-7}
}
The expression of the murine T cell Ag 4-1BB, a member of the TNF-R family, is induced by T cell activation. Previously, we and others had shown that signaling through 4-1BB enhanced proliferative T cell responses. To investigate a potential role for the interaction of 4-1BB with its ligand (4-1BBL) in T cell activation, we studied the ability of a soluble chimera of 4-1BB (4-1BBFc) to interfere with proliferative responses and cytokine production in models of activation dependent in… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
57 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…