Corpus ID: 42859048

Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta.

@article{Bursten1994PotentialRF,
  title={Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta.},
  author={Stuart L. Bursten and Ryan Weeks and J West and Tam Le and T. Wilson and David J. Porubek and James A. Bianco and Jack W Singer and Glenn C. Rice},
  journal={Circulatory shock},
  year={1994},
  volume={44 1},
  pages={
          14-29
        }
}
Tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta), and endotoxin (LPS) are potent pro-inflammatory mediators which induce multiple and diverse biological responses in a wide variety of cell types. However, these pro-inflammatory mediators also have significant overlap and redundancy in their biological effects. This suggests that there is significant diversity in second messenger signal transduction systems induced by these stimuli to explain the diversity in biological… Expand
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