Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.

@article{Gao1991PotentialRF,
  title={Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.},
  author={Minggeng Gao and David Michael Knipe},
  journal={Journal of virology},
  year={1991},
  volume={65 5},
  pages={2666-75}
}
We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was less than 5. Production of HSV types 1 and 2 but not production… CONTINUE READING