Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity

@article{Wu1998PotentialRF,
  title={Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity},
  author={Gen Sheng Wu and Paul Saftig and Christoph Jonathan Peters and Wafik S El-Deiry},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={2177-2183}
}
Cathepsin D (CD), the major intracellular aspartyl protease, is a mediator of IFN-γ and TNF-α induced apoptosis. Using subtractive hybridization screening we isolated CD as an upregulated transcript in PA1 human ovarian cancer cells undergoing adriamycin-induced apoptosis. CD mRNA levels increased in wild-type p53-expressing PA1, ML1 leukemia and U1752 lung cancer cells but not in mutant p53-expressing cells following adriamycin exposure. Overexpression of CD inhibited growth of colon, liver… CONTINUE READING