Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.

Abstract

Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and forms discrete nuclear foci, suggesting its role in DNA damage responses. We show that 53BP1 changed its localization from the detergent soluble to insoluble fraction after treatment of cells with x-ray, but not with ultraviolet or hydroxyurea. Either DNase… (More)

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Cite this paper

@article{Iwabuchi2003PotentialRF, title={Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.}, author={Kuniyoshi Iwabuchi and Balaka Piku Basu and Boris Kysela and Takayuki Kurihara and Masao Shibata and Deyu Guan and Yongheng Cao and Tomio Hamada and Kouji Imamura and Penny A Jeggo and Takayasu Date and Aidan J. Doherty}, journal={The Journal of biological chemistry}, year={2003}, volume={278 38}, pages={36487-95} }