Potential risk of mulberry-drug interaction: modulation on P-glycoprotein and cytochrome P450 3A.

@article{Hsu2013PotentialRO,
  title={Potential risk of mulberry-drug interaction: modulation on P-glycoprotein and cytochrome P450 3A.},
  author={Pei-Wen Hsu and Chi-Sheng Shia and Shiuan-Pey Lin and Pei-dawn Lee Chao and S S Juang and Y Y Hou},
  journal={Journal of agricultural and food chemistry},
  year={2013},
  volume={61 18},
  pages={4464-9}
}
Mulberry is a fruit containing polyphenol antioxidants. Cyclosporine (CSP), a potent immunosuppressant with a narrow therapeutic range, is widely used in transplant patients. This study investigated the effect of co-administration of mulberry on the bioavailability of CSP, a probe drug of P-glycoprotein (P-gp)/cytochrome P450 3A4 (CYP 3A4), in rats and relevant mechanisms. CSP (2.5 mg/kg) was orally administered with and without a single dose or the seventh dose of mulberry (2 g/kg) to rats… CONTINUE READING

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