Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.

@article{Meotti2003PotentialRA,
  title={Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.},
  author={Fl{\'a}via Carla Meotti and Vanessa Corralo Borges and Gilson Rog{\'e}rio Zeni and Jo{\~a}o Batista T Rocha and Cristina Wayne Nogueira},
  journal={Toxicology letters},
  year={2003},
  volume={143 1},
  pages={
          9-16
        }
}
The occupational importance of tellurium and selenium is growing rapidly, but the biochemistry of exposure is poorly understood. Here we report the potential toxic effects of diphenyl diselenide (PhSe)(2), diphenyl ditelluride (PhTe)(2) and Ebselen in rats and mice. The results suggest that (PhTe)(2) is more toxic in rats than mice. (PhSe)(2), (PhTe)(2) and Ebselen are more toxic by intraperitoneal (i.p.) than subcutaneous (s.c.) route. Calculated LD(50) for (PhTe)(2), i.p., was 0.65 micromol… Expand
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