Potential regulation of inflammation in the lung by local metabolism of hydrocortisone.

@article{Schleimer1991PotentialRO,
  title={Potential regulation of inflammation in the lung by local metabolism of hydrocortisone.},
  author={Robert P. Schleimer},
  journal={American journal of respiratory cell and molecular biology},
  year={1991},
  volume={4 2},
  pages={166-73}
}
Human lung tissue converts hydrocortisone to cortisone by the action of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD). Since cortisone is inactive as an antiinflammatory steroid, the action of this enzyme may regulate the local antiinflammatory effects of glucocorticoids in the lung. Minced human lung tissue (100 mg in 500 microliters medium) metabolized approximately 50% of added [3H]hydrocortisone within 2 h in most lung specimens. Metabolism was linear during this period and… CONTINUE READING