Potential radiosensitizing agents. Dinitroimidazoles.

@article{Agrawal1979PotentialRA,
  title={Potential radiosensitizing agents. Dinitroimidazoles.},
  author={K. Agrawal and K. Bears and R. K. Sehgal and J. N. Brown and P. E. Rist and W. Rupp},
  journal={Journal of medicinal chemistry},
  year={1979},
  volume={22 5},
  pages={
          583-6
        }
}
New compounds of the nitroimidazole series have been synthesized as radiosensitizers which selectively sensitize hypoxic cells to the lethal effect of radiation. The reaction of 2,4(5)-dinitroimidazole (2) with chloroethanol or hydrochloric acid yielded 4(5)-nitro-5(4)-chloroimidazole (3), which upon reaction with ethylene oxide yielded the 4-nitro-5-chloroimidazole-1-ethanol (6). Reaction of 2 with ethylene oxide resulted in a mixture of two compounds, the 2,4-dinitroimidazole-1-ethanol (4… Expand
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An efficient radiosynthesis of [18F]fluoromisonidazole.
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An efficient preparation of the hypoxic cell tracer [ 18F]3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol ([18F]fluoromisonidazole) is reported, which is of interest to probe hypoxic tissue in infarcts and tumors. Expand
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Addition of partially purified glutathione S-transferase (GST) did not enhance DNIE-mediated GSH loss in a cell-free system, while misonidazole and KIH-3 did not. Expand
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