• DOI:10.1039/c4fo00009a
• Corpus ID: 27266658

Potential protective effect of highly bioavailable curcumin on an oxidative stress model induced by microinjection of sodium nitroprusside in mice brain.

@article{Nazari2014PotentialPE,
  title={Potential protective effect of highly bioavailable curcumin on an oxidative stress model induced by microinjection of sodium nitroprusside in mice brain.},
  author={Qand Agha Nazari and Yuki Takada-Takatori and Tadashi Hashimoto and Atsushi Imaizumi and Yasuhiko Izumi and Akinori Akaike and Toshiaki Kume},
  journal={Food \& function},
  year={2014},
  volume={5 5},
  pages={
          984-9
        }
}

• Q. Nazari, Yuki Takada-Takatori, +4 authors T. Kume
• Published 25 April 2014
• Biology
• Food & function

Curcumin, a polyphenolic compound has several pharmacological activities, such as anticancer, anti-inflammatory and antioxidant effects. However, curcumin shows poor oral bioavailability. The purpose of this study was to investigate the protective effects of highly bioavailable curcumin, Theracurmin(®), and curcumin, against sodium nitroprusside (SNP)-induced oxidative damage in mice brain. Intrastriatal microinjection of Theracurmin(®) or curcumin with SNP significantly protected against SNP-induced brain damage and motor dysfunction. Oral administration of Theracurmin(®) (1 and 3 g kg(-1), containing 100 and 300 mg kg(-1) curcumin, respectively) significantly protected against SNP-induced brain damage and motor dysfunction. However, oral administration of 300 mg kg(-1) curcumin did not protect against motor dysfunction induced by SNP. These results suggest that curcumin and Theracurmin(®) have protective effects against SNP-induced oxidative damage. Moreover, oral administration of Theracurmin(®), had more potency in protecting against brain damage, suggesting a higher bioavailability of Theracurmin(®) following oral administration.