Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

@article{Cooper1988PotentialPA,
  title={Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.},
  author={Jonathan A Cooper and A C Macauley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 12},
  pages={4232-6}
}
The product of the protooncogene c-src is a protein-tyrosine kinase, p60c-src, that is normally inhibited by phosphorylation at a tyrosine residue close to the C terminus (Tyr-527). If activated by dephosphorylation of Tyr-527, or by other means, p60c-src becomes phosphorylated at a tyrosine residue in the catalytic domain (Tyr-416). To test whether either or both of these tyrosines can be phosphorylated by p60c-src itself, we have created four mutations in c-src. One mutant product can receive… CONTINUE READING