Corpus ID: 7841249

Potential physiological importance of pyrroloquinoline quinone.

@article{Rucker2009PotentialPI,
  title={Potential physiological importance of pyrroloquinoline quinone.},
  author={R. Rucker and Winyoo Chowanadisai and M. Nakano},
  journal={Alternative medicine review : a journal of clinical therapeutic},
  year={2009},
  volume={14 3},
  pages={
          268-77
        }
}
Pyrroloquinoline quinone (PQQ) is a novel biofactor for which a proposition can be made for physiological importance. PQQ was first recognized as an enzyme cofactor in bacteria. It has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughout early biological conception and evolution. PQQ is also a potent plant growth factor. Consequently, for animals and humans, there has been constant exposure to PQQ. In animals, PQQ is reported to… Expand
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Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein
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References

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Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice.
TLDR
Dietary PQQ can influence mitochondrial amount and function, particularly in perinatal and weanling mice, and is associated with growth-related variables in young mice. Expand
The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation
TLDR
PQQ scavenges superoxide without forming toxic levels of H2O2, suggesting that the protective effect of PQQ on stroke might be due, at least in part, to the suppression of peroxynitrite formation. Expand
Protection of pyrroloquinoline quinone against methylmercury-induced neurotoxicity via reducing oxidative stress
TLDR
After pre-treatment of PC12 cells with PQQ prior to MeHg exposure, the MeHG-induced cytotoxicity was significantly attenuated and then the percentage of apoptotic cells and the arrest of S-phase in cell cycle were correspondingly reduced. Expand
Pyrroloquinoline quinone (PQQ) and quinoprotein enzymes.
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This review summarises the characteristics, identification, and measurement of pyrroloquinoline quinone, the prosthetic group of bacterial quinoprotein dehydrogenases whose structures, mechanisms,Expand
Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat.
TLDR
Pyrroloquinoline quinone (PQQ) added to purified diets devoid of PQQ improves indices of perinatal development in rats and mice, and it is proposed that P QQ influences lysine metabolism, but by mechanisms that more likely involve changes in mitochondrial content. Expand
Intestinal Absorption and Tissue Distribution of [14C]Pyrroloquinoline Quinone in Mice
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  • Chemistry, Medicine
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TLDR
PQQ was readily absorbed in the lower intestine, and was excreted by the kidneys (81% of the absorbed dose) within 24 hr, and most of the [14C]PQZ in blood (>95%) was associated with the blood cell fraction, rather than plasma. Expand
The pyrroloquinoline quinone biosynthesis pathway revisited: A structural approach
TLDR
The role and catalytic function for each enzyme involved in this intriguing biosynthesis pathway of Pyrroloquinoline quinone, a bacterial redox active cofactor for numerous alcohol and aldose dehydrogenases, is proposed. Expand
Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts.
TLDR
The results suggest that PQQ stimulates cell proliferation through NO-sensitive Ras-mediated signaling pathways, and protein expression levels of growth-inhibitory molecules such as IkappaB and p27 decreased after PQZ treatment. Expand
Biochemistry: Is pyrroloquinoline quinone a vitamin?
TLDR
The results call into question the identification of PQQ as a new vitamin after it is found that the activity of α-aminoadipic acid-δ-semialdehyde (AAS) dehydrogenase in liver and plasma levels of α,aminoadIPic acid (AAA), both of which act as indicators of lysine degradation in mammals, are not affected by changes in P QQ dietary status. Expand
Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site
TLDR
It appears as if the entire neuroprotective effect of PQQ is attributable to a direct oxidation of the NMDA receptor redox site, and this compound may represent a novel therapeutic approach for the amelioration ofNMDA receptor-mediated neurotoxic injury. Expand
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