Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells.

@article{Secchiero2005PotentialPI,
  title={Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells.},
  author={Paola Secchiero and Elisa Barbarotto and Arianna Gonelli and Mario Tiribelli and Carlotta Zerbinati and Claudio Celeghini and Claudio Agostinelli and Stefano A Pileri and Giorgio Zauli},
  journal={The American journal of pathology},
  year={2005},
  volume={167 6},
  pages={1599-607}
}
Evidence suggests that cyclooxygenase-2 (COX-2) increases tumorigenic potential by promoting resistance to apoptosis. Because B chronic lymphoid leukemia (B-CLL) cells exhibit a defective apoptotic response, we analyzed CD19(+) B lymphocytes purified from the peripheral blood of B-CLL patients. Microarray analysis showed a variable (up to 38-fold) increase in the steady-state mRNA levels of COX-2 in B-CLL lymphocytes compared with normal CD19(+) B lymphocytes. The up-regulation of COX-2 in B… CONTINUE READING

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