Potential of sequential treatment with minocycline and S. aureus specific phage lysin in eradication of MRSA biofilms: an in vitro study

@article{Chopra2015PotentialOS,
  title={Potential of sequential treatment with minocycline and S. aureus specific phage lysin in eradication of MRSA biofilms: an in vitro study},
  author={Shivani Chopra and Kusum Harjai and Sanjay Chhibber},
  journal={Applied Microbiology and Biotechnology},
  year={2015},
  volume={99},
  pages={3201-3210}
}
Lysins are novel class of anti-infectives which are derived from bacteriophage. In the present study, the potential of previously characterised phage borne endolysin MR-10 in eradicating methicillin-resistant Staphylococcus aureus (MRSA) biofilm was evaluated. Scanning electron microscopic examination showed that both ica-positive and ica-negative MRSA formed equally potent mature biofilm. Different approaches were employed to eradicate the young as well as older biofilm formed by both types of… CONTINUE READING
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