Potential of peptide-based enhancers for transdermal delivery.

  title={Potential of peptide-based enhancers for transdermal delivery.},
  author={Luciana B Lopes and Vanessa F M Carvalho and D{\'e}bora P de Lemos},
  journal={Current pharmaceutical design},
  volume={21 20},
The skin presents several advantages as an administration route, including the possibility of localizing drugs in the tissue and overcoming the first-pass effect. However, its use is limited by the barrier function of the tissue, which is provided mainly (but not exclusively) by the stratum corneum. Various strategies to overcome this layer, have been considered over the years, ranging from the use of physical methods such as iontophoresis to wellknown conventional chemical penetration… CONTINUE READING