Potential of old-generation antibiotics to address current need for new antibiotics
@article{Falagas2008PotentialOO, title={Potential of old-generation antibiotics to address current need for new antibiotics}, author={M. Falagas and A. Grammatikos and A. Michalopoulos}, journal={Expert Review of Anti-infective Therapy}, year={2008}, volume={6}, pages={593 - 600} }
Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative solutions; one of the most promising ones is the evaluation and use of old antibiotic compounds. Due to the low-level use of many of the old antibiotic compounds, these have remained active… CONTINUE READING
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References
SHOWING 1-10 OF 85 REFERENCES
Novel approaches to developing new antibiotics for bacterial infections
- Biology, Medicine
- British journal of pharmacology
- 2007
- 172
- PDF
Pharmacokinetics and pharmacodynamics of antimicrobials.
- Medicine
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 2007
- 152
- PDF
Antibacterial drug discovery--then, now and the genomics future.
- Biology, Medicine
- Biochemical pharmacology
- 2006
- 99
Safety and efficacy of glycopeptide antibiotics.
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
- 2005
- 64
- PDF
Glycopeptides: Update on an old successful antibiotic class.
- Medicine, Biology
- Biochemical pharmacology
- 2006
- 93
New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors.
- Biology, Medicine
- Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
- 2002
- 125
Lack of development of new antimicrobial drugs: a potential serious threat to public health.
- Medicine
- The Lancet. Infectious diseases
- 2005
- 471
Natural products--the future scaffolds for novel antibiotics?
- Biology, Medicine
- Biochemical pharmacology
- 2006
- 305
Old antibiotics for infections in critically ill patients
- Medicine
- Current opinion in critical care
- 2007
- 63