Potential of old-generation antibiotics to address current need for new antibiotics

  title={Potential of old-generation antibiotics to address current need for new antibiotics},
  author={M. Falagas and A. Grammatikos and A. Michalopoulos},
  journal={Expert Review of Anti-infective Therapy},
  pages={593 - 600}
  • M. Falagas, A. Grammatikos, A. Michalopoulos
  • Published 2008
  • Biology, Medicine
  • Expert Review of Anti-infective Therapy
  • Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative solutions; one of the most promising ones is the evaluation and use of old antibiotic compounds. Due to the low-level use of many of the old antibiotic compounds, these have remained active… CONTINUE READING
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    Novel approaches to developing new antibiotics for bacterial infections
    • 172
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    Pharmacokinetics and pharmacodynamics of antimicrobials.
    • G. Drusano
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    • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    • 2007
    • 152
    • PDF
    Antibacterial drug discovery--then, now and the genomics future.
    • 99
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    • M. Pucci
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    • 2006
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    • I. Chopra
    • Biology, Medicine
    • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
    • 2002
    • 125
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    • 305
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    • 63