Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

@article{Ishola2014PotentialON,
  title={Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems},
  author={I. Ishola and Charles O. Ochieng and S. Olayemi and M. O. Jimoh and S. Lawal},
  journal={Pharmacology Biochemistry and Behavior},
  year={2014},
  volume={127},
  pages={90-100}
}
  • I. Ishola, Charles O. Ochieng, +2 authors S. Lawal
  • Published 2014
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
  • Vitex doniana Sweet (Verbanaceae) is used in traditional African medicine for the treatment of neurological disorders including depression. In our previous studies, three new phytoecdysteroids were isolated from methanol stem bark extract of V. doniana (VD) (11β-hydroxy-20-deoxyshidasterone, 21-hydroxyshidasterone, and 2,3-acetonide-24-hydroxyecdysone) along with known ecdysteroids. This study was designed to investigate antidepressant-like effect of VD and the isolated phytoecdysteroids in… CONTINUE READING
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