Potential of moclobemide to improve cerebral insufficiency identified using a scopolamine model of aging and dementia

  title={Potential of moclobemide to improve cerebral insufficiency identified using a scopolamine model of aging and dementia},
  author={Keith A Wesnes and R Anand and Thomas Lorscheid},
  journal={Acta Psychiatrica Scandinavica},
After a baseline performance assessment, 28 healthy male volunteers received subcutaneous injections of scopolamine hydrobromide to induce deficits in memory, attention and cognitive processes. Subsequent performance testing established the decrements caused by the scopolamine, and then each subject was given one of 3 investigational drugs including moclobemide, or placebo, according to a latin‐square design. Parallel versions of the test procedures were used to assess drug effects on the… Expand
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