Potential of glyburide to reduce intracerebral edema in brain metastases.

  title={Potential of glyburide to reduce intracerebral edema in brain metastases.},
  author={Drexell Hunter Boggs and J. Marc Simard and A Steven and Minesh P. Mehta},
  journal={Expert review of neurotherapeutics},
  volume={14 4},
Metastatic disease to the brain results in significant morbidity because of edema in the central nervous system. Current anti-edema therapies are either expensive or result in unwanted long-term side effects. Sulfonylurea receptor 1 (Sur1) is a transmembrane protein that, when activated in the central nervous system, allows for unregulated sodium influx into cells, a process that has been linked to cytotoxic edema formation in ischemic stroke, subarachnoid hemorrhage, spinal cord injury… CONTINUE READING


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