Potential of biopartitioning micellar chromatography as an in vitro technique for predicting drug penetration across the blood-brain barrier.

@article{EscuderGilabert2004PotentialOB,
  title={Potential of biopartitioning micellar chromatography as an in vitro technique for predicting drug penetration across the blood-brain barrier.},
  author={Laura Escuder-Gilabert and M Molero-Monfort and Rosa Mar{\'i}a Villanueva-Cama{\~n}as and Salvador Sagrado and Mar{\'i}a Jos{\'e} Medina-Hern{\'a}ndez},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2004},
  volume={807 2},
  pages={193-201}
}
The blood-brain barrier (BBB) is considered to be the main barrier to drug transport into the central nervous system (CNS). The BBB restricts the passive diffusion of many drugs from blood to brain. The ease with which any particular drug diffuses across the BBB is determined largely by the molecular features of drugs, and it is therefore possible to predict the BBB permeability of a drug from its molecular structure. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid… CONTINUE READING

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