Potential of Concentration Monitoring Data for a Short Half‐Life Drug: Analysis of Pharmacokinetic Variability for Moclobemide

@article{Gexfabry1995PotentialOC,
  title={Potential of Concentration Monitoring Data for a Short Half‐Life Drug: Analysis of Pharmacokinetic Variability for Moclobemide},
  author={M. Gex-fabry and Androniki E. Balant-Gorgia and Luc P. Balant},
  journal={Therapeutic Drug Monitoring},
  year={1995},
  volume={17},
  pages={39–46}
}
The pharmacokinetic variability of moclobemide, a new short half-life reversible selective inhibitor of monoamine oxidase (MAO) was investigated through analysis of concentrations measured during early open clinical use. Eighty-nine depressed patients, aged 21–96 years, were included in the present study. Doses ranged from 200 to 900 mg/day, and the time interval between blood sampling and last drug intake on the previous day was between 8 and 23 h. Intraindividual variability was generally… Expand
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