Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma.

  title={Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma.},
  author={Jesse L Berry and Liya Xu and A. Linn Murphree and Subramanian Krishnan and Kevin Stachelek and Emily Zolfaghari and Kathleen R McGovern and Thomas C. Lee and Anders Carlsson and Peter A Kuhn and Jonathan W. Kim and David Cobrinik and James B. Hicks},
  journal={JAMA ophthalmology},
  volume={135 11},
Importance Retinoblastoma (Rb) is one of the first tumors to have a known genetic etiology. However, because biopsy of this tumor is contraindicated, it has not been possible to define the effects of secondary genetic changes on the disease course. Objective To investigate whether the aqueous humor (AH) of Rb eyes has sufficient tumor-derived DNA to… CONTINUE READING