Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells.

@article{Fujino2013PotentialNE,
  title={Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells.},
  author={Kotaro Fujino and Yurina Ogura and Kazunori Sato and Taku Nedachi},
  journal={Neuroscience letters},
  year={2013},
  volume={557 Pt B},
  pages={148-53}
}
Nutrient availability is one of the most important signals regulating cellular fates including cell growth, differentiation, and death. Recent evidence suggests that the NAD(+)-dependent histone deacetylase sirtuin 1 (SIRT1) plays a prominent role in linking changes in nutritional availability with cellular fate regulation. SIRT1 expression is observed in neurons, yet the expressional and functional regulation of this protein is not fully understood. In the present study, we examined whether… CONTINUE READING

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