Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.

  title={Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.},
  author={Tomas de Paulis and Yatendra Kumar and Lars George Johansson and Sten R{\"a}msby and Lennart Florvall and H{\aa}kan Hall and K Angeby-M{\"o}ller and Sven Ove Ogren},
  journal={Journal of medicinal chemistry},
  volume={28 9},
A series of substituted 6-methoxysalicylamides were synthesized from their corresponding 2,6-dimethoxybenzamides by demethylation of one methoxy group with boron tribromide. Substituted 6-methoxysalicylamides having a lipophilic aromatic substituent in the 3-position para with respect to the methoxy group, e.g. a bromo or an iodo atom or an ethyl or a propyl group, and having an (S)-N-(1-alkyl-2-pyrrolidinyl)methyl moiety as the side chain were found to be potent blockers of [3H]spiperone… 

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