Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.

  title={Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.},
  author={Tomas de Paulis and Yatendra Kumar and Lars George Johansson and Sten Ingvar Raemsby and Lennart Florvall and H. Hall and K Angeby-M{\"o}ller and Sven Ove Ogren},
  journal={Journal of medicinal chemistry},
  volume={28 9},
A series of substituted 6-methoxysalicylamides were synthesized from their corresponding 2,6-dimethoxybenzamides by demethylation of one methoxy group with boron tribromide. Substituted 6-methoxysalicylamides having a lipophilic aromatic substituent in the 3-position para with respect to the methoxy group, e.g. a bromo or an iodo atom or an ethyl or a propyl group, and having an (S)-N-(1-alkyl-2-pyrrolidinyl)methyl moiety as the side chain were found to be potent blockers of [3H]spiperone… Expand
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Quantitative Structure‐Affinity Relationships of Dopamine D2 Receptor Antagonists: A Comparison between Orthopramides and 6‐Methoxysalicylamides
A large series of orthopramides (= 2-methoxybenzamides), 6-methoxysalicylamides, and 2,6-dimethoxybenzamides were examined for their affinity to the dopamine D2 receptor. The binding data wereExpand
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