Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary 1H‐NMR spectroscopy

  title={Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary 1H‐NMR spectroscopy},
  author={Kyu-Bong Kim and J. Yang and S. Kwack and H. Kim and D. H. Ryu and Yeon-Joo Kim and Jung Yun Bae and Duck Soo Lim and S. M. Choi and M. Kwon and D. Bang and S. K. Lim and Y. Kim and Geum-Sook Hwang and Byungmu Lee},
  journal={Journal of Applied Toxicology},
  • Kyu-Bong Kim, J. Yang, +12 authors Byungmu Lee
  • Published 2013
  • Chemistry, Medicine
  • Journal of Applied Toxicology
  • A metabolomics approach using proton nuclear magnetic resonance (NMR) was applied to investigate metabolic alterations following adriamycin (ADR) treatment for gastric adenocarcinoma. After BALB/c‐nu/nu mice were implanted with human gastric adenocarcinoma, ADR (1 or 3 mg kg−1 per day) was intraperitoneally administered for 5 days. Urine was collected on days 2 and 5 and analyzed by NMR. The levels of trimethylamine oxide (TMAO, ×0.3), hippurate (×0.3) and taurine (×0.6) decreased significantly… CONTINUE READING
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