Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes.

@article{Castagnoli1997PotentialMB,
  title={Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes.},
  author={Neal Castagnoli and John M. Rimoldi and Jr Bloomquist and Kay P Castagnoli},
  journal={Chemical research in toxicology},
  year={1997},
  volume={10 9},
  pages={924-40}
}
A major theme explored in this review is the MAO-and cytochrome P450-catalyzed alpha-carbon oxidations of selected cyclic tertiary amines to give iminium metabolites that undergo further chemical modifications to form known or potentially toxic products. The most dramatic illustration of this type of bioactivation process is the conversion of the parkinsonian-inducing neurotoxin MPTP (23) by brain MAO-B to the iminium (dihydropyridinium) metabolite 24 which is oxidized further to the pyridinium… CONTINUE READING

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