Potential medicinal plants for CNS disorders: an overview

@article{Kumar2006PotentialMP,
  title={Potential medicinal plants for CNS disorders: an overview},
  author={Vikas Kumar},
  journal={Phytotherapy Research},
  year={2006},
  volume={20}
}
  • Vikas Kumar
  • Published 1 December 2006
  • Medicine
  • Phytotherapy Research
Although very few drugs are currently approved by regulatory authorities for treating multi‐factorial ailments and disorders of cognition such as Alzheimer's disease, certain plant‐derived agents, including, for example, galantamine and rivastigmine (a semi‐synthetic derivative of physostigmine) are finding an application in modern medicine. However, in Ayurveda, the Indian traditional system of medicine which is more than 5000 years old, selected plants have long been classified as ‘medhya… 
Nootropic medicinal plants: Therapeutic alternatives for Alzheimer’s disease
TLDR
The importance of standardization and metabolite profiling of medicinal plants in the field of pharmacognosy is addressed, and the checkpoints of taking translational drug development from the level of laboratory research up to patient treatment are precisely mentioned.
Therapeutic Potential of Phytoconstituents in Management of Alzheimer's Disease
  • A. Singh, S. Rai, +8 authors M. Singh
  • Medicine
    Evidence-based complementary and alternative medicine : eCAM
  • 2021
TLDR
The primitive remedies as well as the development of herbal remedies for AD management are provided, which may be useful in the discovery and advancement of drugs, thus extending new leads for neurodegenerative diseases such as AD.
Ethnopharmacological review of native traditional medicinal plants for brain disorders
TLDR
Well known medicinal plants of Indian origin, including Withania somnifera, Bacopa monniera, Centella asiatica, Convolvulus pluricaulis, Emblica officinalis and Ocimum sanctum reputed for their effectiveness in CNS disorders are discussed.
Phytochemicals Having Neuroprotective Properties from Dietary Sources and Medicinal Herbs
Many neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease, anxiety, cerebrovascular impairment, depression, seizures, Parkinson's disease, etc. are predominantly appearing in
Herbal Medicine as Neuroprotective Potential Agent in Human and Animal Models: A Historical Overview
TLDR
People who eat more vegetables and fruits may be less risk of developing certain diseases caused by neurological dysfunction, and indication recommends that chronic herbs used to cure neurological symptoms are recommended.
Ayurvedic medicinal plants for Alzheimer's disease: a review
TLDR
This review gathers research on various medicinal plants that have shown promise in reversing the Alzheimer's disease pathology and summarizes information concerning the phytochemistry, biological, and cellular activities and clinical applications of these various plants in order to provide sufficient baseline information that could be used in drug discovery campaigns and development process.
Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview.
ETHNOPHARMACOLOGICAL RELEVANCE For thousands of years, different cultural groups have used and transformed natural resources for medicinal purposes focused on psychological or neurological
Neuroprotective potential of phytochemicals
TLDR
It was observed in the review that a number of herbal medicines used in Ayurvedic practices as well Chinese medicines contain multiple compounds and phytochemicals that may have a neuroprotective effect which may prove beneficial in different neuropsychiatric and neurodegenerative disorders.
Pharmacological exploration of traditional plants for the treatment of neurodegenerative disorders
TLDR
A range of traditional plants imparts effects via acetylcholinesterase activity, β‐amyloid peptide formation in plaques, neurotrophic factors and through antioxidant activity, which reveal rich source of primary and secondary metabolites for improving health problems.
HERBAL MEDICINES AS NEUROPROTECTIVE AGENT: A MECHANISTIC APPROACH
TLDR
The role of herbal plants and their phytoconstituents against neurodegenerative diseases and other related disorders are highlighted, focusing on their mechanism of action and therapeutic potential.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 193 REFERENCES
Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders.
TLDR
Herbal remedies that have demonstrable psychotherapeutic activities have provided a potential to psychiatric pharmaceuticals and deserve increased attention in future studies.
A review of herbal medicines for psychiatric disorders.
TLDR
Evidence of the efficacy of herbal preparations in treating psychiatric conditions is growing, but translating the results of efficacy studies into effective treatments for patients is hampered by the chemical complexity of the products, the lack of standardization of commonly available preparations, and the paucity of well-controlled studies.
Potential for interaction of kava and St. John's wort with drugs.
TLDR
There is very little evidence to substantiate actual pharmacokinetic and/or pharmacodynamic interaction between drugs and kava or St. John's wort with pharmaceutical agents and as a result reveals the urgent need for detailed investigations to identify clinically significant interactions for these herbal remedies that have the potential to cause adverse effects.
Herbal remedies in the United States: potential adverse interactions with anticancer agents.
TLDR
It is suggested that health care professionals and consumers should be aware of the potential for adverse interactions with these herbs, question their patients on their use of them, and urge patients to avoid herbs that could confound their cancer care.
Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability
TLDR
There is a need for longer-term controlled studies with some of these compounds (particularly valerian) and aromatherapy constitutes a tantalising possibility, but how practical a form of treatment this may be remains to be determined.
Adverse-Effect Profile of Kava
TLDR
The data support the safety of kava in treating anxiety at 280 mg kava lactones/day for 4 weeks, including findings from a study of its use in generalized anxiety disorder.
Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease.
TLDR
Results suggest that some of the constituents of the non-flavone fraction of EGb 761 possess neuroprotective and anti-apoptotic capacity, and that bilobalide is the most potent one.
Kava extracts: safety and risks including rare hepatotoxicity.
TLDR
A critical analysis of the suspected cases in Germany reveals that only in 1 single patient a very probable causal relationship could be established between kava treatment and the development of toxic liver disease due to a positive result of an unscheduled reexposure test, whereas in another patient there might be a possible association.
Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trials and guidelines fail to consider.
  • V. Schulz
  • Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2003
TLDR
Given the limited therapeutic options for DAT, treatment with EGb still appears to be the method of choice compared to the ChE inhibitors, but the relatively small differences are called into question by the occurrence of drug-specific side effects with the Ch E inhibitors.
A review of clinical and experimental observations about antidepressant actions and side effects produced by Hypericum perforatum extracts.
TLDR
Some of the controversial evidence derived from clinical and experimental studies suggesting that H. perforatum exerts antidepressant-like actions are reviewed, and some of its side effects, such as nausea, rash, fatigue, restlessness, photosensitivity, acute neuropathy, and even episodes of mania and serotonergic syndrome when administered simultaneously with other antidepressant drugs are reviewed.
...
1
2
3
4
5
...