Potential mechanisms of the sleep therapies for depression

  title={Potential mechanisms of the sleep therapies for depression},
  author={B. Ringel and Martin P. Szuba},
  journal={Depression and Anxiety},
Sleep deprivation for one night has been investigated as a treatment for depression since the first publications describing its antidepressant properties almost 30 years ago [Pflug and Tolle, 1971: Int Pharmacopsychiatry 6:187–196]. It remains a field of active research. It is the only intervention consistently demonstrated to produce next‐day antidepressant results. This makes sleep deprivation an exciting and unique tool to study the pathophysiology of depressive disorders and to formulate… 
Neuroendocrine and Behavioral Correlates of Sleep Deprivation: A Synthesis of Neurobiological and Psychological Mechanisms
This chapter briefly reviews neuroendocrine aspects of sleep deprivation in healthy and depressed subjects, and looks at emotional and behavioral results in response toSleep deprivation in clinical samples, and tries to figure out how these correlates concomitantly interact with each other.
No influence of a functional polymorphism within the serotonin transporter gene on partial sleep deprivation in major depression
  • T. Baghai, C. Schule, B. Bondy
  • Psychology, Biology
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2003
The previously reported influence of the serotonin transporter gene on PSD outcome in bipolar depression could not be confirmed in unipolar depressed patients and 5-HTTLPR variants had no influence on reduction of depressive symptoms on day 2 or relapse on day 3.
Pills or Sleep Deprivation? Sleep-Deprivation as a Therapeutic Option Intervention in Psychiatry
The use of sleep deprivation in clinical conditions is aimed primarily at preventing depression and its recurrence, as well as in cases resistant to pharmacotherapy, and should be used under close supervision of a physician.
Sick and tired: does sleep have a vital role in the immune system?
There is increasing evidence that sleep deprivation has detrimental effects on the immune response, indicating that sleep should be considered a vital part of the immune system and that there is a reciprocal relationship between sleep and immunity.
Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects
Current Concepts of Neurophysiological Factors in Central Regulatory Mechanism of Rapid Eye Movement Sleep: A Review.
  • E. Ezenwanne
  • Biology, Psychology
    The West Indian medical journal
  • 2015
It is concluded from this review that neural factors involved in the central mechanisms of REM sleep are not fully understood and lends further credence to the notion that REM sleep is crucial and probably the most important sleep phase.
Meta-analysis of the antidepressant response to sleep deprivation and its correlates: towards a better antidepressant therapy
This book aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.


The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis.
The authors suggest that these phenomenological observations concerning relapse with a night of sleep or with naps after successful sleep deprivation would be compatible with the existence of a sleep-associated depressogenic process.
Partial sleep deprivation as therapy for depression.
Partial sleep deprivation significantly reduced the depression symptoms in patients with endogenous depression and the interindividual variations were considerable; deterioration was rare, and in 75% of the cases improvement occurred.
Is sleep deprivation useful in the treatment of depression?
Although the literature appears to demonstrate the efficacy of sleep deprivation as a potentiation strategy, these treatment studies have substantial methodological shortcomings and well-designed pilot studies indicate that sleep deprivation may hasten the onset of action of thymoleptic medications.
Therapeutic sleep deprivation in a depressed patient: prolongation of response with concurrent thyroxine
The results suggest that the beneficial effects of SD may be mediated by thyroid hormones, or associated activity in the hypothalamic‐pituitary‐adrenal axis.
Serial partial sleep deprivation in depression--clinical effects and dexamethasone suppression test results.
A trend was found indicating that concurrent psychotropic drug treatment enhances the beneficial effect of serial PSDs, and no pretreatment variable except the degree of improvement after the first PSD was predictive for therapeutic effects of the entire PSD series.
REM sleep reduction effects on depression syndromes.
It is suggested that substantial REM sleep reduction has antidepressant activity, and since imipramine and other drug antidepressants reduceREM sleep much more so than nonantidepressant drugs, that an antidepressant "mechanism" of drugs resides in their capacity to substantially reduce REM sleep.
Sleep deprivation therapy