Potential mechanisms of estrogen quinone carcinogenesis.

  title={Potential mechanisms of estrogen quinone carcinogenesis.},
  author={Judy L Bolton and Gregory R J Thatcher},
  journal={Chemical research in toxicology},
  volume={21 1},
There is a clear association between the excessive exposure to estrogens and the development of cancer in hormone-sensitive tissues (breast, endometrium). It has become clear that there are likely multiple overlapping mechanisms of estrogen carcinogenesis. One major pathway is the extensively studied hormonal pathway, by which estrogen stimulates cell proliferation through nuclear estrogen receptor (ER)-mediated signaling, thus resulting in an increased risk of genomic mutations during DNA… CONTINUE READING


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