Potential mechanism of interleukin-8 production from lung cancer cells: an involvement of EGF-EGFR-PI3K-Akt-Erk pathway.

@article{Zhang2012PotentialMO,
  title={Potential mechanism of interleukin-8 production from lung cancer cells: an involvement of EGF-EGFR-PI3K-Akt-Erk pathway.},
  author={Yong Zhang and Linyan Wang and Miaomiao Zhang and Meiling Jin and Chunxue Bai and Xiangdong Wang},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 1},
  pages={35-43}
}
Tumor inflammatory microenvironment is considered to play the role in the sensitivity of tumor cells to therapies and prognosis of lung cancer patients. Interleukin-8 (IL-8) is one of critical chemo-attractants responsible for leukocyte recruitment, cancer proliferation, and angiogenesis. The present study aimed at investigating potential mechanism of IL-8… CONTINUE READING