Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia.


Commonly used general anesthetics can have adverse effects on the developing brain by triggering apoptotic neurodegeneration, as has been documented in the rat. The rational of our study was to examine the molecular mechanisms that contribute to the apoptotic action of propofol anesthesia in the brain of 7-day-old (P7) rats. The down-regulation of nerve… (More)
DOI: 10.1016/j.ijdevneu.2008.12.005