Potential linkage disequilibrium between schizophrenia and locus D22S278 on the long arm of chromosome 22.

@article{Moises1995PotentialLD,
  title={Potential linkage disequilibrium between schizophrenia and locus D22S278 on the long arm of chromosome 22.},
  author={Hans Moises and Lin Yang and Tao Li and B. H. Havsteen and Rolf Fimmers and Max P. Baur and Xiehe Liu and Irving I Gottesman},
  journal={American journal of medical genetics},
  year={1995},
  volume={60 5},
  pages={465-7}
}
Locus D22S278 at 22q12 has been implicated in schizophrenia by sib-pair analysis. In order to replicate these results, we performed the transmission test for linkage disequilibrium (TDT) in 113 unrelated schizophrenic patients and their 226 parents. Evidence for potential linkage disequilibrium was obtained between schizophrenia and allele 243 of the marker AFM 182xd12 at the locus D22S278 (P = 0.02). The results of our study suggest a detectable oligogenic gene in a multigene system for… CONTINUE READING

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