Potential involvement of retroviral elements in human dementias.

  title={Potential involvement of retroviral elements in human dementias.},
  author={L. Manuelidis and G H Murdoch and E. E. Manuelidis},
  journal={Ciba Foundation symposium},
Creutzfeldt-Jakob disease (CJD) is a dementia of humans caused by a class of infectious agents with several biological properties similar to those of conventional viruses. The molecular nature of this group of agents is enigmatic, for neither an agent-specific nucleic acid nor a non-host protein has yet been identified. Recent transmissions of familial CJD dementias to rodents suggest that this class of agent can be integrated into the germline. Furthermore, tissue culture studies indicate that… CONTINUE READING