Potential involvement of oxidative stress in induction of neurodegenerative diseases: Actions, mechanisms and neurotherapeutic potential of natural antioxidants

  title={Potential involvement of oxidative stress in induction of neurodegenerative diseases: Actions, mechanisms and neurotherapeutic potential of natural antioxidants},
  author={G. L. S. Oliveira and F. R. M. Oliveira and R. M. Freitas},
  journal={African Journal of Pharmacy and Pharmacology},
Several studies have shown that oxidative damage to various organs of a given organism is involved in causing various diseases, and in this context, the brain is highly vulnerable to oxidative stress because of its high metabolic rate, low capacity of cell regeneration, small amounts of enzymatic and non-enzymatic antioxidants. Oxidative stress is caused by an imbalance in cell redox state, in which there is excessive production of reactive oxygen species and/or failure of antioxidant defense… Expand

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