Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

@article{Yudoh2005PotentialIO,
  title={Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function},
  author={Kazuo Yudoh and Nguyen van Trieu and Hiroshi Nakamura and Kayo Hongo-Masuko and Tomohiro Kato and Kusuki Nishioka},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={R380 - R391}
}
Oxidative stress leads to increased risk for osteoarthritis (OA) but the precise mechanism remains unclear. We undertook this study to clarify the impact of oxidative stress on the progression of OA from the viewpoint of oxygen free radical induced genomic instability, including telomere instability and resulting replicative senescence and dysfunction in human chondrocytes. Human chondrocytes and articular cartilage explants were isolated from knee joints of patients undergoing arthroplastic… CONTINUE READING

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