Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams.

@article{RodrguezPena2006PotentialIO,
  title={Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams.},
  author={Rebeca Rodr{\'i}guez-Pena and Soledad L{\'o}pez and Cristobalina Mayorga and Cristina Ant{\'u}nez and T D Fernandez and Mar{\'i}a Jos{\'e} Alvarez Torres and Miguel Blanca},
  journal={The Journal of allergy and clinical immunology},
  year={2006},
  volume={118 4},
  pages={949-56}
}
BACKGROUND Although the involvement of T cells in delayed reactions to drugs has been studied, little is known about the interaction between the drug and the antigen-presenting cells. Dendritic cells (DCs) are professional antigen-presenting cells essential for initiating T-cell responses. Their ability is regulated in a process known as maturation, by which they modulate the effector immune response. OBJECTIVES We studied the role of DCs in subjects who had a delayed-type hypersensitivity… CONTINUE READING
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