Potential interactions of prescription and over‐the‐counter medications having antioxidant capabilities with radiation and chemotherapy

@article{Lemmo2015PotentialIO,
  title={Potential interactions of prescription and over‐the‐counter medications having antioxidant capabilities with radiation and chemotherapy},
  author={Walter Lemmo},
  journal={International Journal of Cancer},
  year={2015},
  volume={137}
}
  • Walter Lemmo
  • Published 2015
  • Medicine
  • International Journal of Cancer
Oncology patients undergoing radiation treatment and chemotherapy routinely use prescription and/or over‐the counter medications either as part of pre‐existing comorbid conditions or in the context of conventional treatment management. A growing amount of data suggest that commonly used pharmaceuticals possess antioxidant properties, which may also partially explain some of their therapeutic efficacy. Clinical research is continuing on how such agents interact during chemotherapy and radiation… Expand
New natural antioxidants
Antioxidants are, no doubt, an essential part of an optimal health and even traditional doctors support the importance of an appropriate contribution of antioxidants taken through food. AntioxidantsExpand
Antioxidant vitamins and their effect on immune system
TLDR
Although vitamins are required in specific doses to maintain functional immune system, they mostly used as supplements, and vitamin C supplementation, for example, has been shown to reduce the duration and severity of upper respiratory infections. Expand
Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species
TLDR
The anti-tumor activity of specific MKIs, such as regorafen ib and sorafenib, is altered by the cellular redox status, suggesting that uncontrolled antioxidant intake during HCC treatment should be avoided or only endorsed to diminish chemotherapy-induced side effects, always under medical scrutiny. Expand
Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth.
TLDR
This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells. Expand
Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations
As the global need for drugs getting increases, the necessity of novel and effective drugs are the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The presentExpand
Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations.
TLDR
From the results, few compounds of 4a-m were found to have anti-inflammatory properties by showing excellent COX-2 inhibition and HRBC membrane stabilization properties and ADMET prediction results were valuable to screen the most effective pyrazole derivatives to establish them as future COx-2 inhibitors or anti- inflammatory drugs. Expand
Alternative Medicine
TLDR
An outline of all the details of one single patient’s history signs, symptoms, diagnosis, treatment, outcome and prognosis, as well as several case reports, are outlined. Expand
Adapting Cognitive-Behavior Therapy for Insomnia in Cancer Patients
TLDR
This work explores potential adaptations that can be made to standard CBT-I for cancer patients and finds that addressing unique physical and psychosocial health issues that may interfere with standard CBTs can play a role in improving treatment adherence and efficacy. Expand
Medicines and Oral Treatments
Agrohomeopathy is the use of homeopathic remedies and homeopathic principles in the treatment of diseases of plants.
Novel and green ultrasonic-assisted liquid–liquid microextraction method based on a nanopolymer for extraction of ferulic acid, gallic acid, cinnamic acid and rutin from vegetable oils
A novel, simple, sensitive and green ultrasonic-assisted liquid–liquid microextraction method based on a synthetic citric acid–glycerol nanopolymer solution was used for the extraction of antioxidantExpand
...
1
2
...

References

SHOWING 1-10 OF 165 REFERENCES
Re: Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?
TLDR
The commentary by Lawenda et al. concerning the use of antioxidants during cancer therapy caught the authors' attention because they included their clinical trial among others in their discussion of chemotherapy and antioxidants, and it became apparent that this conclusion is probably premature and represents a gaping void between the data presented and interpretation thereof. Expand
Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?
TLDR
It is concluded that the use of supplemental antioxidants during chemotherapy and radiation therapy should be discouraged because of the possibility of tumor protection and reduced survival. Expand
Systematic Review: Generating Evidence-Based Guidelines on the Concurrent Use of Dietary Antioxidants and Chemotherapy or Radiotherapy
TLDR
The clinical cancer research community should cooperate and focus new studies on the use of a specific combination of antioxidant and chemotherapy or radiotherapy, and determine optimal doses for a specific cancer setting. Expand
Pros and cons of antioxidant use during radiation therapy.
TLDR
This review has analyzed published data that are used in support of each hypothesis regarding the use of antioxidants during radiation therapy, and has revealed that the current controversies can be resolved, if the results obtained from one experimental design are not extrapolated to the other. Expand
Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors
TLDR
New in vivo results demonstrate glucocorticoid-induced chemotherapy resistance in xenografted prostate cancer and the need for prospective clinical studies as well as for detailed mechanistic studies of GC-induced cell-type specific pro- and anti-apoptotic signaling. Expand
Corticosteriod-induced chemotherapy resistance in urological cancers
Purpose: Glucocorticoids such as dexamethasone are widely used for medication of urological diseases, e.g. as co-treatment of advanced prostate cancer, to improve appetite, weight loss, fatigue,Expand
Attenuation of Doxorubicin-induced Cardiotoxicity by Tadalafil: A Long Acting Phosphodiesterase-5 Inhibitor.
TLDR
The results showed that tadalafil improved left ventricular function and survival by attenuating DOX-induced apoptosis and cardiac oxidative stress without interfering with the anti-tumor efficacy of DOX in both in vitro and in vivo tumor models. Expand
Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer
TLDR
Data show that DEX induces therapy resistance in pancreatic carcinoma cells and raise the question whether GC-mediated protection of tumour cells from cancer therapy may be dangerous for patients. Expand
Metformin: taking away the candy for cancer?
TLDR
The role of diabetes mellitus type 2 and insulin resistance in carcinogenesis, the preclinical rationale and potential mechanisms of met formin's anti-cancer effect and the current and future clinical developments of metformin as a novel anti- cancer drug are discussed. Expand
Effects of Antiepileptic Drugs on Antioxidant and Oxidant Molecular Pathways: Focus on Trace Elements
TLDR
There is a large number of recent studies about the role of antioxidants or neuroprotectants in clinical and experimental models of epilepsy, and new antiepileptic drugs are more prone to restore antioxidant redox systems in brain and neurons. Expand
...
1
2
3
4
5
...