Potential indicators of reproductive toxicity: testicular sperm production and epididymal sperm number, transit time, and motility in Fischer 344 rats.

@article{Blazak1985PotentialIO,
  title={Potential indicators of reproductive toxicity: testicular sperm production and epididymal sperm number, transit time, and motility in Fischer 344 rats.},
  author={W F Blazak and T. Ernst and Brett Stewart},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1985},
  volume={5 6 Pt 1},
  pages={1097-103}
}
Comprehensive assessment of the effects of chemicals on male reproductive functioning requires study of effects on spermatogenesis and the quality of spermatozoa produced. As potential indicators of toxic effects, we have examined sperm production rate (SPR) and epididymal sperm numbers, transit time, and motility (percentage motile cells and swimming speeds) in Fischer-344 (F-344) rats. Groups (n = 14 or 15) of rats at 6, 8, 10, 15, and 20 weeks of age were studied to investigate the… CONTINUE READING

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