Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression.

@article{Ban2005PotentialIA,
  title={Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression.},
  author={Sadayuki Ban and Ken-ichi Ishikawa and Seiko Kawai and Kumiko Koyama-Saegusa and Atsuko Ishikawa and Yutaka Shimada and Johji Inazawa and Takashi Imai},
  journal={Journal of radiation research},
  year={2005},
  volume={46 1},
  pages={
          43-50
        }
}
Morphologically heterogeneous colonies were formed from a cultured cell line (KYSE70) established from one human esophageal carcinoma tissue. Two subclones were separated from a single clone (clone13) of KYSE70 cells. One subclone (clone13-3G) formed mainly mounding colonies and the other (clone 13-6G) formed flat, diffusive colonies. X-irradiation stimulated the cells to dedifferentiate from the mounding state to the flat, diffusive state. Clone 13-6G cells were more radiosensitive than the… CONTINUE READING

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