Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms

@article{Fbin2007PotentialIF,
  title={Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms},
  author={Tibor K{\'a}roly F{\'a}bi{\'a}n and P{\'a}l Fej{\'e}rdy and Minh T. N. Nguyen and Csaba Sőti and P{\'e}ter Csermely},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
  year={2007},
  volume={55},
  pages={91-98}
}
Molecular chaperones were considered to be intracellular, but there is increasing evidence demonstrating their cytoprotective and immune modulator properties outside the cell. The major extracellular chaperone (Hsp70) was also found in saliva, indicating a possible effect of Hsp70 on mucosal surfaces. Here we summarize the immune-modulatory role of the 70-kDa stress protein family, with special attention on the potential impact of salivary Hsp70 on oral defense mechanisms. There are three major… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 89 references

Stressinduced extracellular Hsp72 is a functionally significant danger signal to the immune system

J. Campisi, T H.Leem, M. Fleshner
Cell Stress Chaperones, • 2003
View 6 Excerpts
Highly Influenced

HSP-70 is present in human saliva

T K.Fábián, J. Gáspár, +4 authors P. Fejérdy
Med. Sci. Monit., • 2003
View 6 Excerpts
Highly Influenced

Heat shock proteins as regulators of the immune response

A G.Pockley
Lancet • 2003
View 8 Excerpts
Highly Influenced

Activation of natural killer cells by heat shock protein 70.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group • 2002
View 5 Excerpts
Highly Influenced

Heat shock protein 70 is a potent activator of the human complement system

Z. Prohászka, M. Sing, +4 authors G. Füst
Cell Stress Chaperones, • 2002
View 4 Excerpts
Highly Influenced

Heat shock protein 70: role in antigen presentation and immune stimulation.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group • 2002
View 7 Excerpts
Highly Influenced

Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization

I V.Guzhova, A C.Arnholdt, +6 authors B A.Margulis
Cell Stress Chaperones, • 1998
View 5 Excerpts
Highly Influenced

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